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Addeck A, Croes K, van Langenhove K, Denison MS, Afify AS, Gao Y, Elskens M, Baeyens W (2014) Time-integrated monitoring of dioxin-like polychlorinated biphenyls (dl-PCBs) in aquatic environments using the ceramic toximeter and the CALUX bioassay. Talanta 120:413–418
Aufenvenne K, Rice RH, Hausser I, Oji V, Hennies HC, Rio MD, Traupe H, Larcher F (2012) Long-term faithful recapitulation of transglutaminase 1-deficient lamellar ichthyosis in a skin-humanized mouse model, and insights from proteomic studies. J. Invest. Dermatol. 132(7):1918–1921
Baston DS, Denison MS (2011) Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta 83(5):1415–1421
Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345–1348
Brander SM, Connon RE, He G, Hobbs JA, Smalling KL, Teh SJ, White JW, Werner I, Denison MS, Cherr GN, Craft JA (2013) From ‘Omics to Otoliths: Responses of an Estuarine Fish to Endocrine Disrupting Compounds across Biological Scales. PLoS ONE 8(9):e74251
Brander SM, He G, Smalling KL, Denison MS, Cherr GN (2012) The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem 31(12):2848–2855
Brennan JC, Denison MS, Holstege DM, Magiatis P, Dallas JL, Gutierrez EG, Soshilov AA, Millam JR (2013) 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complement Altern Med 13:133
Burmistrov V, Morisseau C, Lee KSS, Shihadih DS, Harris TR, Butov GM, Hammock BD (2014) Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg. Med. Chem. Lett. 24(9):2193–2197
Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN (2012) Tetramethylenedisulfotetramine alters Ca²? dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol. Sci. 130(2):362–372
Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN (2014) Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol. Pharmacol. 85(4):630–639
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P (2014) Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc. Natl. Acad. Sci. U.S.A. 111(22):8167–8172
Croes K, Colles A, Koppen G, Galan S de, Vandermarken T, Govarts E, Bruckers L, Nelen V, Schoeters G, van Larebeke N, Denison MS, Mampaey M, Baeyens W (2013) Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. Talanta 113:99–105
Croes K, van Langenhove K, Den Hond E, Bruckers L, Colles A, Koppen G, Loots I, Nelen V, Schoeters G, Nawrot T, van Larebeke N, Denison MS, Vandermarken T, Elskens M, Baeyens W (2011) Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II. Talanta 85(5):2484–2491
Croes K, Vandermarken T, van Langenhove K, Elskens M, Desmedt M, Roekens E, Denison MS, van Larebeke N, Baeyens W (2012) Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: correlation between the CALUX bioassay and GC-HRMS. Chemosphere 88(7):881–887
DeGroot DE, Denison MS (2014) Nucleotide Specificity of DNA Binding of the Aryl Hydrocarbon Receptor:ARNT Complex Is Unaffected by Ligand Structure. Toxicol. Sci. 137(1):102–113
DeGroot DE, Hayashi A, Denison MS (2014) Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. Arch. Biochem. Biophys. 541:13–20
Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B (2011) Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol. Sci. 124(1):1–22
Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN (2011) Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Mol. Pharmacol. 79(3):420–431
Feng W, Cherednichenko G, Ward CW, Padilla IT, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN (2010) Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochem. Pharmacol. 80(4):512–521
Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN, Knollmann BC (2012) Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin. Mol. Pharmacol. 82(5):993–1000
Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS (2013) Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52(4):714–725
Fritsch EB, Connon RE, Werner I, Davies RE, Beggel S, Feng W, Pessah IN (2013) Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in fathead minnow (Pimephales promelas). Environ Sci Technol 47(4):2008–2017
Fritsch EB, Pessah IN (2013) Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 140-141C:204–212
He G, Tsutsumi T, Zhao B, Baston DS, Zhao J, Heath-Pagliuso S, Denison MS (2011) Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol. Sci. 123(2):511–522
He G, Zhao B, Denison MS (2011) Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environ. Toxicol. Chem. 30(8):1915–1925
He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS (2014) Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators. In: Caldwell GW, Yan Z (eds) Optimization in Drug Discovery. Methods in Pharmacology and Toxicology. Humana Press, Totowa, NJ, pp 221–235
Hu Q, He G, Zhao J, Soshilov A, Denison MS, Zhang A, Yin H, Fraccalvieri D, Bonati L, Xie Q, Zhao B (2013) Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS ONE 8(6):e66258
Hu Q, Rice RH, Qin Q, Phinney BS, Eigenheer RA, Bao W, Zhao B (2013) Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure. J. Proteome Res. 12(11):5340–5347
Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD (2011) Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc. Natl. Acad. Sci. U.S.A. 108(12):5093–5097
Jaikanlaya C, Settachan D, Denison MS, Ruchirawat M, van den Berg M (2009) PCBs contamination in seafood species at the Eastern Coast of Thailand. Chemosphere 76(2):239–249
Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z (2013) Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett 218(3):253–259
Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Zapletalova M, Anzenbacher P, Dvorak Z (2013) Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett 221(1):1–8
Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy, Mohammed H M E, Lein PJ, Veng-Pedersen P, Lehmler H (2012) 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393–11401
Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN (2012) Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J. Neurochem. 123(4):613–621
Kennedy K, Macova M, Bartkow ME, Hawker DW, Zhao B, Denison MS, Mueller JF (2010) Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmos Pollut Res 1(1):50–58
Kennedy K, Macova M, Leusch F, Bartkow ME, Hawker DW, Zhao B, Denison MS, Mueller JF (2009) Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity. Anal Bioanal Chem 394(5):1413–1421
Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN (2011) Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ. Health Perspect. 119(4):519–526
Kim KH, Pessah IN (2011) Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. Neurotoxicology 32(6):981–985
Koenig CM, Lango J, Pessah IN, Berman RF (2012) Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicol Teratol 34(6):571–580
Kujal P, Certíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Cervenka L (2014) Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin. Exp. Pharmacol. Physiol. 41(3):227–237
Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA (2014) The Environmental Neurotoxicant PCB 95 Promotes Synaptogenesis via Ryanodine Receptor-Dependent miR132 Upregulation. J Neurosci 34(3):717–725
Lin T, Crumrine D, Ackerman LD, Santiago J, Roelandt T, Uchida Y, Hupe M, Fabriàs G, Abad JL, Rice RH, Elias PM (2012) Cellular changes that accompany shedding of human corneocytes. J. Invest. Dermatol. 132(10):2430–2439
Lin Y, Pessah IN, Puschner B (2013) Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography-tandem mass spectrometry in human serum and plasma. Talanta 113:41–48
Liu J, Qiu H, Morisseau C, Hwang SH, Tsai H, Ulu A, Chiamvimonvat N, Hammock BD (2011) Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol. Appl. Pharmacol. 255(2):200–206 (Core A)
Magby JP, Neal AP, Atchison WD, Pessah IP, Shafer TJ (2011) Channelopathies: summary of the hot topic keynotes session. Neurotoxicology 32(5):661–665
Magiatis P, Pappas P, Gaitanis G, Mexia N, Melliou E, Galanou M, Vlachos C, Stathopoulou K, Skaltsounis AL, Marselos M, Velegraki A, Denison MS, Bassukas ID (2013) Malassezia Yeasts Produce a Collection of Exceptionally Potent Activators of the Ah (Dioxin) Receptor Detected in Diseased Human Skin. J. Invest. Dermatol.
Morisseau C (2013) Role of epoxide hydrolases in lipid metabolism. Biochimie 95(1):91–95
Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD (2011) Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal. Biochem. 414(1):154–162
Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L (2011) New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model 51(11):2868–2881
Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN (2013) Structure-Activity Relationship of Selected Meta- and Para-Hydroxylated Non-Dioxin Like Polychlorinated Biphenyls: From Single RyR1 Channels to Muscle Dysfunction. Toxicol. Sci. 136(2):500–513
Palumbo AJ, Denison MS, Doroshov SI, Tjeerdema RS (2009) Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus). Environ. Toxicol. Chem. 28(8):1749–1755
Pessah IN, Cherednichenko G, Lein PJ (2010) Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol. Ther. 125(2):260–285
Phillips MA, Qin Q, Hu Q, Zhao B, Rice RH (2013) Arsenite suppression of BMP signaling in human keratinocytes. Toxicol. Appl. Pharmacol. 269(3):290–296
Reznikova TV, Phillips MA, Patterson TJ, Rice RH (2010) Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation. Mol. Carcinog. 49(4):398–409
Rice RH (2011) Proteomic analysis of hair shaft and nail plate. J Cosmet Sci 62(2):229–236
Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Schmuth M, Gruber R (2013) Distinguishing ichthyoses by protein profiling. PLoS ONE 8(10):e75355
Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Sundberg JP (2012) Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS ONE 7(12):e51956
Rice RH, Phillips MA, Sundberg JP (2011) Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. J. Invest. Dermatol. 131(9):1936–1938
Rice RH, Winters BR, Durbin-Johnson BP, Rocke DM (2013) Chicken corneocyte cross-linked proteome. J Proteome Res 12(2):771–776
Rice RH, Xia Y, Alvarado RJ, Phinney BS (2010) Proteomic analysis of human nail plate. J. Proteome Res. 9(12):6752–6758
Schebb NH, Buchholz BA, Hammock BD, Rice RH (2012) Metabolism of the antibacterial triclocarban by human epidermal keratinocytes to yield protein adducts. J. Biochem. Mol. Toxicol. 26(6):230–234
Sinitsyna NN, Reznikova TV, Qin Q, Song H, Phillips MA, Rice RH (2010) Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicol. Appl. Pharmacol. 243(3):275–282
Soshilov AA, Denison MS (2014) Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis. Mol. Cell. Biol. 34(9):1707–1719
Stamou M, Streifel KM, Goines PE, Lein PJ (2013) Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol 36:3–16
Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ (2014) Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab. Dispos. 42(2):239–244
Ta TA, Koenig CM, Golub MS, Pessah IN, Qi L, Aronov PA, Berman RF (2011) Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicol Teratol 33(3):393–404
Villalon Landeros R, Morisseau C, Yoo HJ, Fu SH, Hammock BD, Trainor BC (2012) Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain. Endocrinology
Wall RJ, He G, Denison MS, Congiu C, Onnis V, Fernandes A, Bell DR, Rose M, Rowlands JC, Balboni G, Mellor IR (2012) Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. Toxicology 297(1-3):26–33
Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ (2012) PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ. Health Perspect. 120(7):1003–1009
Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ (2012) PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ. Health Perspect. 120(7):997–1002
Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi L, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM (2012) Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum. Mol. Genet. 21(11):2399–2411
Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ (2014) PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms. Toxicol. Sci.
Zhang W, Li H, Dong H, Liao J, Hammock BD, Yang G (2013) Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res. 33(12):5261–5271
Zhao B, Baston DS, Khan E, Sorrentino C, Denison MS (2010) Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci China Chem 53(5):1010–1016
Zhao B, Bohonowych JES, Timme-Laragy A, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS (2013) Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS ONE 8(2):e56860
Zhao B, DeGroot DE, Hayashi A, He G, Denison MS (2010) CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol. Sci. 117(2):393–403
Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I (2009) Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J. Biol. Chem. 284(41):28156–28163 (Core A)
Bettaieb A, Nagata N, Aboubechara D, Chahed S, Morisseau C, Hammock BD, Haj FG (2013) Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-Induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue. J. Biol. Chem. (Core A)
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P (2011) Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. 108(3):324–334 (Core A)
Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH (2013) Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase. J. Med. Chem. (Core A)
Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN (2012) Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc. Natl. Acad. Sci. U.S.A. 109(35):14158–14163 (Core A)
Falck D, Schebb NH, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WMA (2013) Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia 76(1-2):13–21 (Core A)
Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi X, Goldman DH, Morisseau C, Hammock BD, Campbell WB (2009) 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J. Med. Chem. 52(16):5069–5075 (Core A)
Gardell AM, Qin Q, Rice RH, Li J, Kültz D (2014) Derivation and osmotolerance characterization of three immortalized tilapia (Oreochromis mossambicus) cell lines. PLoS ONE 9(5):e95919 (Core B)
Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD (2013) Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg (Core A)
Huang H, Tanaka H, Hammock BD, Morisseau C (2009) Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal. Biochem. 391(1):11–16 (Core A)
Hwang SH, Wagner KM, Morisseau C, Liu J, Dong H, Wecksler AT, Hammock BD (2011) Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J. Med. Chem. 54(8):3037–3050 (Core A)
Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD (2013) Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorg Med Chem Lett 23(13):3732–3737 (Core A)
Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S (2012) Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. J. Cardiovasc. Pharmacol. 60(1):70–75 (Core A)
Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KSS, Rogawski MA, Morisseau C, Hammock BD (2013) Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures. PLoS ONE 8(12):e80922 (Core A)
Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW (2013) Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Arch. Insect Biochem. Physiol. (Core A)
Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD (2013) Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem. Mol. Biol. 43(3):219–228 (Core A)
Kanematsu M, Hayashi A, Denison MS, Young TM (2009) Characterization and potential environmental risks of leachate from shredded rubber mulches. Chemosphere 76(7):952–958 (Project 1)
Kasagami T, Kim I, Tsai H, Nishi K, Hammock BD, Morisseau C (2009) Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg. Med. Chem. Lett. 19(6):1784–1789 (Core A)
Kim I, Nishi K, Kasagami T, Morisseau C, Liu J, Tsai H, Hammock BD (2012) Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg. Med. Chem. Lett. 22(18):5889–5892 (Core A)
Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA (2011) Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am. J. Physiol. Endocrinol. Metab. 300(4):E691-8 (Core A)
Lee KSS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD (2013) Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal. Biochem. 434(2):259–268 (Core A)
Liu J, Lin Y, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD (2013) Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci 48(4-5):619–627 (Core A)
Liu J, Park S, Morisseau C, Hwang SH, Hammock BD, Weiss RH (2009) Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol. Cancer Ther. 8(8):2193–2203 (Core A)
Liu J, Tsai H, Hwang SH, Jones PD, Morisseau C, Hammock BD (2009) Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br. J. Pharmacol. 156(2):284–296 (Core A)
Luria A, Morisseau C, Tsai H, Yang J, Inceoglu B, Taeye B de, Watkins SM, Wiest MM, German JB, Hammock BD (2009) Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am. J. Physiol. Endocrinol. Metab. 297(2):E375-83 (Core A)
Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD (2009) Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol 10(6):589–599 (Core A)
Morisseau C, Hammock BD (2013) Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol 53:37–58 (Core A)
Morisseau C, Inceoglu B, Schmelzer K, Tsai H, Jinks SL, Hegedus CM, Hammock BD (2010) Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J. Lipid Res. 51(12):3481–3490 (Core A)
Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD (2009) Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ. Health Perspect. 117(12):1867–1872 (Core A)
Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD (2013) Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg. Med. Chem. Lett. (Core A)
Morisseau C, Sahdeo S, Cortopassi G, Hammock BD (2013) Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem 434(1):105–111 (Core A)
Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD (2012) Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem. Biophys. Res. Commun. 419(4):796–800 (Core A)
Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee, Kin Sing S, Kodani SD, Hammock BD (2014) Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J. Lipid Res. 55(6):1131–1138 (Core A)
Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD (2009) Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol. Toxicol. 25(3):217–225 (Core A)
Rice RH, Vidrio EA, Kumfer BM, Qin Q, Willits NH, Kennedy IM, Anastasio C (2009) Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate. Chem. Biol. Interact. 181(3):359–365 (Project 7)
Rose TE, Morisseau C, Liu J, Inceoglu B, Jones PD, Sanborn JR, Hammock BD (2010) 1-Aryl-3-(1-acylpiperidin-4-yl) urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J. Med. Chem. 53(19):7067–7075 (Core A, Core D)
Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH (2014) Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab. Dispos. 42(7):1098–1102 (Core A, Core B)
Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD (2011) Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem 400(5):1359–1366 (Core A)
Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD (2011) Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ. Sci. Technol. 45(7):3109–3115 (Project 3, Core A)
Schuchardt JP, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb NH (2014) Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins Leukot. Essent. Fatty Acids 90(2-3):27–37 (Core A)
Ulu A, Stephen Lee KS, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD (2014) An Omega-3 Epoxide of Docosahexaenoic Acid Lowers Blood Pressure in Angiotensin-II-Dependent Hypertension. J. Cardiovasc. Pharmacol. 64(1):87–99 (Core A)
Ulu A, Appt S, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD (2012) Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br. J. Pharmacol. 165(5):1401–1412 (Core A)
Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif A, Liu J, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD (2013) Anti-inflammatory Effects of Omega-3 Polyunsaturated Fatty Acids and Soluble Epoxide Hydrolase Inhibitors in Angiotensin-II Dependent Hypertension. J. Cardiovasc. Pharmacol. (Core A)
Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD (2013) Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur. J. Pharmacol. 700(1-3):93–101 (Core A)
Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433–446 (Core A)
Yueh M, Li T, Evans RM, Hammock B, Tukey RH (2012) Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS ONE 7(6):e37705 (Core A)
Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2013) Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530–6535 (Core A)
Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2014) Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A. (Core A)
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