Project 7 - Nanoscale Particle Remediation

Project Title	Remediation and Health Effects
Personnel	Project Leader: Dr. Ian Kennedy, Professor of Mechanical & Aeronautical Engineering Senior Investigator: Dr. Cort Anastasio, Professor of Land, Air and Water Resources
Issue	Remediation of Superfund sites can release nanoscale particles into the environment, along with hazardous vapors. The health effects of these complex mixtures and materials, especially emerging materials produced by the nanotechnology industry, are not sufficiently well understood. It has been hypothesized that the adverse health effects due to exposure to environmental particles (e.g., airborne particulate matter) is, at least in part, due to generation of reactive oxygen species (ROS), but more data are needed to test this mechanism.
Objectives	(I) using a laboratory combustion system to create complex mixtures of toxic by-products emitted from thermal processing of materials that contain brominated flame retardants; (II) characterizing the generation of reactive oxygen species from nanoscale materials in the environment; and (III) making use of nanotechnology to answer questions that have arisen in earlier studies of nanoparticle toxicity.
Research Activities	In the first aim, this project is constructing a small, laboratory-scale system to simulate the thermal processing of materials containing brominated flame retardants; the gaseous and particulate by-products of this process are being examined by other projects in this program using bioassays for polybrominated diphenyl ethers (PBDEs) and brominated dioxins and furans. In the second aim we are quantitatively measuring two of the most important ROS – hydroxyl radical (OH) and hydrogen peroxide (H2O2) – formed by nanoparticles in a cell-free surrogate lung fluid and cell cultures. We are also examining how simulated atmospheric reactions alter the ability of nanoparticles to form ROS. In the third aim we are synthesizing a range of novel, multi-functional nanoparticles in order to study several questions related to nanomaterial toxicity, in part in conjunction with other projects in the UC Davis Superfund Program.
Publications	2010 - Most Recent 2005 - 2010 Project Period
Research Brief	207 Particulate matter pollution: A particular problem for the young?