Project 2 - Biosensors

Project Title	Development of Rapid, Miniaturized Biosensors
Personnel	Project Leader: Dr. Ian Kennedy, Professor of Mechanical & Aeronautical Engineering Senior Investigators: Dr. Michael Denison, Professor of Environmental Toxicology Dr. David Horsley, Associate Professor of Mechanical & Aeronautical Engineering
Issue	Conventional bioassay technologies call for faster and more sensitive upgrades.
Objectives	It is the goal of this project, Biosensors, to apply new and emerging technologies to implement bioassays that our colleagues at Davis have developed, with improvements in speed and/or sensitivity compared to conventional methods.
Research Activities	Several new schemes for detection are being tested, including a nanowell format for trapping and interrogating our non-bleaching nanoparticle labels for DNA and immunoassays; a magnetic/luminescent nanoparticle format for DNA assays; and a nanostructured liquid core waveguide for enhancement of fluorescence detection. The targets will include the pyrethroid metabolite 3-PBA, emerging problem compounds such as TCC, TCS and PBDE, and genes for microbes that are used in bioremediation activities. A sensor for TCDD and related compounds are being developed based on AhR technology.
Publications	2010 - Most Recent 2005 - 2010 Project Period
Research Brief	216 New Highly Sensitive ON-Chip Nanoparticle Immunoassay