Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ (2011) Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J. Neurochem. 117(4):632–642
Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y (2009) Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 106(2):564–569
Alihosseini F, Lango J, Ju K, Hammock BD, Sun G (2010) Mutation of bacterium Vibrio gazogenes for selective preparation of colorants. Biotechnol. Prog. 26(2):352–360
Barile D, Marotta M, Chu C, Mehra R, Grimm R, Lebrilla CB, German JB (2010) Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry. J. Dairy Sci. 93(9):3940–3949
Barkauskas DA, Rocke DM (2010) A general-purpose baseline estimation algorithm for spectroscopic data. Anal. Chim. Acta 657(2):191–197
Baumann A, Lohmann W, Rose T, Ahn KC, Hammock BD, Karst U, Schebb NH (2010) Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites. Drug Metab. Dispos. 38(12):2130–2138
Bordiga M, Travaglia F, Meyrand M, German JB, Lebrilla CB, Coïsson JD, Arlorio M, Barile D (2012) Identification and characterization of complex bioactive oligosaccharides in white and red wine by a combination of mass spectrometry and gas chromatography. J. Agric. Food Chem. 60(14):3700–3707
Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L (2010) Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin. Sci. 118(10):617–632
Chawengsub Y, Gauthier KM, Nithipatikom K, Hammock BD, Falck JR, Narsimhaswamy D, Campbell WB (2009) Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. J. Biol. Chem. 284(45):31280–31290
Dallas DC, Martin WF, Strum JS, Zivkovic AM, Smilowitz JT, Underwood MA, Affolter M, Lebrilla CB, German JB (2011) N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry. J. Agric. Food Chem. 59(8):4255–4263
Eiserich JP, Yang J, Morrissey BM, Hammock BD, Cross CE (2012) Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions. Ann. N. Y. Acad. Sci. 1259:1–9
Froehlich JW, Dodds ED, Barboza M, McJimpsey EL, Seipert RR, Francis J, An HJ, Freeman S, German JB, Lebrilla CB (2010) Glycoprotein expression in human milk during lactation. J. Agric. Food Chem. 58(10):6440–6448
Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ (2013) Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. J. Biol. Chem. 288(33):23696–23703
Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ (2013) Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Prostaglandins Leukot. Essent. Fatty Acids 89(5):351–358
German JB, Zivkovic AM, Dallas DC, Smilowitz JT (2011) Nutrigenomics and personalized diets: What will they mean for food? Annu Rev Food Sci Technol 2:97–123
Hall LM, Kimlin MG, Aronov PA, Hammock BD, Slusser JR, Woodhouse LR, Stephensen CB (2010) Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J. Nutr. 140(3):542–550
Hwang SH, Wecksler AT, Wagner K, Hammock BD (2013) Rationally designed multitarget agents against inflammation and pain. Curr. Med. Chem. 20(13):1783–1799
Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD (2012) Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc. Natl. Acad. Sci. U.S.A. 109(28):11390–11395
Kubala L, Schmelzer KR, Klinke A, Kolarova H, Baldus S, Hammock BD, Eiserich JP (2010) Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic. Biol. Med. 48(10):1311–1320
Li N, Liu J, Qiu H, Harris TR, Sirish P, Hammock BD, Chiamvimonvat N (2011) Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest Heart Fail 17(1):42–46
Li N, Liu J, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N (2009) Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J. Mol. Cell. Cardiol. 47(6):835–845
Lin Y, Ubels JL, Schotanus MP, Yin Z, Pintea V, Hammock BD, Watsky MA (2012) Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr. Eye Res. 37(10):871–87
Liu J, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang S, Chiamvimonvat N, Hammock BD (2010) Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochem. Pharmacol. 79(6):880–887
Lu C, Schoenfeld R, Shan Y, Tsai H, Hammock B, Cortopassi G (2009) Frataxin deficiency induces Schwann cell inflammation and death. Biochim. Biophys. Acta 1792(11):1052–1061
Lundström SL, Yang J, Källberg HJ, Thunberg S, Gafvelin G, Haeggström JZ, Grönneberg R, Grunewald J, van Hage M, Hammock BD, Eklund A, Wheelock ÅM, Wheelock CE (2012) Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS ONE 7(3):e33780
Lundström SL, Yang J, Brannan JD, Haeggström JZ, Hammock BD, Nair P, O'Byrne P, Dahlén S, Wheelock CE (2013) Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res 57(8):1378–1389
Nording ML, Yang J, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM (2013) Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS ONE 8(10):e76575
Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD (2010) Endogenous Levels of Five Fatty Acid Metabolites in Exhaled Breath Condensate to Monitor Asthma by High-Performance Liquid Chromatography: Electrospray Tandem Mass Spectrometry. IEEE Sens J 10(1):123–130
Oberbauer AM, German JB, Murray JD (2011) Growth hormone enhances arachidonic acid metabolites in a growth hormone transgenic mouse. Lipids 46(6):495–504
Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio J, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC (2012) Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J. Clin. Invest. 122(1):178–191
Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW (2013) Epoxyeicosanoids promote organ and tissue regeneration. Proc. Natl. Acad. Sci. U.S.A. 110(33):13528–13533
Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B (2013) Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sci.
Qiu H, Li N, Liu J, Harris TR, Hammock BD, Chiamvimonvat N (2010) Soluble Epoxide Hydrolase Inhibitors and Heart Failure. Cardiovasc Ther
Qiu H, Liu J, Wei D, Li N, Yamoah EN, Hammock BD, Chiamvimonvat N (2012) Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc. Res. 95(3):336–345
Rayo J, Muñoz L, Rosell G, Hammock BD, Guerrero A, Luque FJ, Pouplana R (2010) Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. J Mol Model 16(11):1753–1764
Schebb NH, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt JP (2014) Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins Other Lipid Mediat
Schebb NH, Inceoglu B, Rose T, Wagner K, Hammock BD (2011) Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Anal Methods 3(2):420–428
Schuchardt JP, Schmidt S, Kressel G, Dong H, Willenberg I, Hammock BD, Hahn A, Schebb NH (2013) Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostaglandins Leukot. Essent. Fatty Acids
Schuchardt JP, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb NH (2014) Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat. 109-111:23–31
Sirish P, Li N, Liu J, Lee KSS, Hwang SH, Qiu H, Zhao C, Ma SM, López JE, Hammock BD, Chiamvimonvat N (2013) Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc. Natl. Acad. Sci. U.S.A.
Smilowitz JT, Zivkovic AM, Wan YY, Watkins SM, Nording ML, Hammock BD, German JB (2013) Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res 57(8):1319–1335
Stephensen CB, Zerofsky M, Burnett DJ, Lin Y, Hammock BD, Hall LM, McHugh T (2012) Ergocalciferol from mushrooms or supplements consumed with a standard meal increases 25-hydroxyergocalciferol but decreases 25-hydroxycholecalciferol in the serum of healthy adults. J. Nutr. 142(7):1246–1252
Stewart DN, Lango J, Nambiar KP, Falso MJS, FitzGerald PG, Rocke DM, Hammock BD, Buchholz BA (2013) Carbon turnover in the water-soluble protein of the adult human lens. Mol. Vis. 19:463–475
Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD (2010) Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. Eur J Pharm Sci 40(3):222–238
Van Bogaert I, Zhang G, Yang J, Liu J, Ye Y, Soetaert W, Hammock BD (2013) Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. J. Lipid Res. 54(11):3215–3219
Vanrell L, Gonzalez-Techera A, Hammock BD, Gonzalez-Sapienza G (2013) Nanopeptamers for the development of small-analyte lateral flow tests with a positive readout. Anal. Chem. 85(2):1177–1182
Wang L, Yang J, Guo L, Uyeminami D, Dong H, Hammock BD, Pinkerton KE (2012) Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 46(5):614–622
Wettersten HI, Hee Hwang S, Li C, Shiu EY, Wecksler AT, Hammock BD, Weiss RH (2013) A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol. Ther. 14(3):278–285
Yakes EA, Arsenault JE, Islam MM, Ahmed T, German JB, Drake C, Hossain MB, Lewis BL, Rahman AS, Jamil KM, Brown KH (2011) Dietary intake of polyunsaturated fatty acids among breast-feeding and non-breast-feeding 24- to 48-month-old children in Bangladesh. J. Pediatr. Gastroenterol. Nutr. 52(3):351–359
Yakes EA, Arsenault JE, Munirul Islam M, Hossain MB, Ahmed T, Bruce German J, Gillies LA, Shafiqur Rahman A, Drake C, Jamil KM, Lewis BL, Brown KH (2011) Intakes and breast-milk concentrations of essential fatty acids are low among Bangladeshi women with 24-48-month-old children. Br. J. Nutr. 105(11):1660–1670
Yang J, Dong H, Hammock BD (2011) Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Curr. Opin. Lipidol. 22(3):197–203
Yang J, Eiserich JP, Cross CE, Morrissey BM, Hammock BD (2012) Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic. Biol. Med. 53(1):160–171
Yang J, Schmelzer K, Georgi K, Hammock BD (2009) Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal. Chem. 81(19):8085–8093
Yang J, Solaimani P, Dong H, Hammock B, Hankinson O (2013) Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. J Toxicol Sci 38(6):833–836
Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel, Christoph F A, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD (2014) Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Cell Mol. Biol.
Yin Z, Pintea V, Lin Y, Hammock BD, Watsky MA (2011) Vitamin D enhances corneal epithelial barrier function. Invest. Ophthalmol. Vis. Sci. 52(10):7359–7364
Zhang G, Kodani S, Hammock BD (2013) Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog. Lipid Res. 53C:108–123
Zhang W, Liao J, Li H, Dong H, Bai H, Yang A, Hammock BD, Yang G (2012) Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency. Mol. Carcinog.
Zhang W, Yang AL, Liao J, Li H, Dong H, Chung YT, Bai H, Matkowskyj KA, Hammock BD, Yang G (2012) Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig. Dis. Sci. 57(10):2580–2591
Zivkovic AM, Barile D (2011) Bovine milk as a source of functional oligosaccharides for improving human health. Adv Nutr 2(3):284–289
Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD (2012) Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics 8(6):1102–1113
Ahn KC, Gee SJ, Kim H, Aronov PA, Vega H, Krieger RI, Hammock BD (2011) Immunochemical analysis of 3-phenoxybenzoic acid, a biolmarker of forestry worker exposure to pyrethroid insecticides. Anal Bioanal Chem 401(4):1285–1293 (Project 3)
Ahn KC, Gee SJ, Tsai H, Bennett D, Nishioka MG, Blum A, Fishman E, Hammock BD (2009) Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environ. Sci. Technol. 43(20):7784–7790 (Project 3)
Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I (2009) Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J. Biol. Chem. 284(41):28156–28163 (Project 5)
Bettaieb A, Nagata N, Aboubechara D, Chahed S, Morisseau C, Hammock BD, Haj FG (2013) Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-Induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue. J. Biol. Chem. (Project 5)
Buchholz BA, Zermeno P, Hwang HM, Young TM, Guilderson TP (2010) Measuring Submicron-Sized Fractionated Particulate Matter on Aluminum Impactor Disks. Radiocarbon 52(2):278–285 (Project 1)
Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D (2010) Free flow electrophoresis separation and AMS quantitation of C-naphthalene-protein adducts. Nucl Instrum Methods Phys Res B 268(7-8):1324–1327 (Project 4, Core B)
Carlomagno M, Mathó C, Cantou G, Sanborn JR, Last JA, Hammock BD, Roel A, González D, González-Sapienza G (2010) A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture. J. Agric. Food Chem. 58(7):4367–4371 (Project 3)
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P (2011) Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. 108(3):324–334 (Project 5)
Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH (2013) Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase. J. Med. Chem. (Project 5)
Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN (2012) Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc. Natl. Acad. Sci. U.S.A. 109(35):14158–14163 (Project 5)
Davis BB, Liu J, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE (2011) The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem. Biophys. Res. Commun. 410(3):494–500 (Project 6)
Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi X, Goldman DH, Morisseau C, Hammock BD, Campbell WB (2009) 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition (Project 5)
Falck D, Schebb NH, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WMA (2013) Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. Chromatographia 76(1-2):13–21 (Project 5)
García-Nieto E, Nichkova M, Yáñez L, Costilla-Salazar R, Torres-Dosal A, Gee SJ, Hammock BD, Juárez-Santacruz L, Díaz-Barriga F (2010) Assessment of dioxin-like soil contamination in Mexico by enzyme-linked immunosorbent assay. Arch. Environ. Contam. Toxicol. 58(4):918–926 (Project 3)
Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D (2013) Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J. Exp. Biol. 216(Pt 24):4615–4625 (Core B)
Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD (2013) Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg (Project 5)
Huang H, Tanaka H, Hammock BD, Morisseau C (2009) Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal. Biochem. 391(1):11–16 (Project 5)
Hwang SH, Wagner KM, Morisseau C, Liu J, Dong H, Wecksler AT, Hammock BD (2011) Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J. Med. Chem. 54(8):3037–3050 (Project 5)
Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD (2013) Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorg Med Chem Lett 23(13):3732–3737 (Project 5)
Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S (2012) Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. J. Cardiovasc. Pharmacol. 60(1):70–75 (Project 5)
Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KSS, Rogawski MA, Morisseau C, Hammock BD (2013) Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures. PLoS ONE 8(12):e80922 (Project 5)
Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW (2013) Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Arch. Insect Biochem. Physiol. (Project 5)
Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD (2013) Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem. Mol. Biol. 43(3):219–228 (Project 5)
Kasagami T, Kim I, Tsai H, Nishi K, Hammock BD, Morisseau C (2009) Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg. Med. Chem. Lett. 19(6):1784–1789 (Project 5)
Kim H, Ahn KC, González-Techera A, González-Sapienza GG, Gee SJ, Hammock BD (2009) Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides. Anal. Biochem. 386(1):45–52 (Project 3)
Kim H, Rossotti MA, Ahn KC, González-Sapienza GG, Gee SJ, Musker R, Hammock BD (2010) Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Anal. Biochem. 401(1):38–46 (Project 3)
Kim I, Nishi K, Kasagami T, Morisseau C, Liu J, Tsai H, Hammock BD (2012) Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg. Med. Chem. Lett. 22(18):5889–5892 (Project 5)
Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA (2011) Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am. J. Physiol. Endocrinol. Metab. 300(4):E691-8 (Project 5)
Lee KSS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD (2013) Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal. Biochem. 434(2):259–268 (Project 5)
Liu J, Lin Y, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD (2013) Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. Eur J Pharm Sci 48(4-5):619–627 (Project 5)
Liu J, Park S, Morisseau C, Hwang SH, Hammock BD, Weiss RH (2009) Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol. Cancer Ther. 8(8):2193–2203 (Project 5)
Liu J, Tsai H, Hwang SH, Jones PD, Morisseau C, Hammock BD (2009) Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br. J. Pharmacol. 156(2):284–296 (Project 5)
Luria A, Morisseau C, Tsai H, Yang J, Inceoglu B, Taeye B de, Watkins SM, Wiest MM, German JB, Hammock BD (2009) Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am. J. Physiol. Endocrinol. Metab. 297(2):E375-83 (Project 5)
Ma ZY, Dosev D, Nichkova M, Gee SJ, Hammock BD, Kennedy IM (2009) Synthesis and bio-functionalization of multifunctional magnetic Fe(3)O(4)@Y(2)O(3):Eu nanocomposites. J Mater Chem 19(27):4695–4700 (Project 2, Project 3)
Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD (2009) Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol 10(6):589–599 (Project 5)
Morisseau C, Hammock BD (2013) Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu. Rev. Pharmacol. Toxicol. 53:37–58 (Project 5)
Morisseau C, Inceoglu B, Schmelzer K, Tsai H, Jinks SL, Hegedus CM, Hammock BD (2010) Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J. Lipid Res. 51(12):3481–3490 (Project 5)
Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD (2009) Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ. Health Perspect. 117(12):1867–1872 (Project 5)
Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD (2013) Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg. Med. Chem. Lett. (Project 5)
Morisseau C, Sahdeo S, Cortopassi G, Hammock BD (2013) Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem 434(1):105–111 (Project 5)
Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD (2012) Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem. Biophys. Res. Commun. 419(4):796–800 (Project 5)
Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee, Kin Sing S, Kodani SD, Hammock BD (2014) Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J. Lipid Res. 55(6):1131–1138 (Project 5)
Nichkova M, Fu X, Yang Z, Zhong P, Sanborn JR, Chang D, Gee SJ, Hammock BD (2009) Immunochemical screening of pesticides (simazine and cypermethrin) in orange oil. J. Agric. Food Chem. 57(13):5673–5679 (Project 3)
Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD (2009) Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol. Toxicol. 25(3):217–225 (Project 5)
Ranganathan A, Paradise GA, Hansen CA, McCoy MR, Gee SJ, Zhong P, Chang D, Hammock BD (2013) Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones. J Agric Food Chem 61(28):6964–6970 (Project 3)
Ranganathan A, Paradise GA, Hansen CA, McCoy MR, Gee SJ, Zhong P, Chang D, Hammock BD (2013) Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones. J Agric Food Chem 61(28):6964–697 (Project 3)
Rose TE, Morisseau C, Liu J, Inceoglu B, Jones PD, Sanborn JR, Hammock BD (2010) 1-Aryl-3-(1-acylpiperidin-4-yl) urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J. Med. Chem. 53(19):7067–7075 (Project 5, Core D)
Rossotti MA, Carlomagno M, Gonza´lez-Techera A, Hammock BD, Last J, Gonza´lez-Sapienza G (2010) Phage Anti-Immunocomplex Assay for Clomazone: Two-Site Recognition Increasing Assay Specificity and Facilitating Adaptation into an On-Site Format. Anal. Chem. (Project 3)
Schebb NH, Franze B, Maul R, Ranganathan A, Hammock BD (2012) In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites. Drug Metab. Dispos. 40(1):25–31 (Project 3)
Schebb NH, Ahn KC, Dong H, Gee SJ, Hammock BD (2012) Whole blood is the sample matrix of choice for monitoring systemic triclocarban levels. Chemosphere 87(7):825–827 (Project 3)
Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD (2011) Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem 400(5):1359–1366 (Project 5)
Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD (2011) Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ. Sci. Technol. 45(7):3109–3115 (Project 3, Project 5)
Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH (2014) Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab. Dispos. 42(7):1098–1102 (Project 5, Core B)
Schuchardt JP, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb NH (2014) Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins Leukot. Essent. Fatty Acids 90(2-3):27–37 (Project 5)
Shen S, Zhang F, Zeng S, Tian Y, Chai X, Gee S, Hammock BD, Zheng J (2009) Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts. Anal. Chem. 81(7):2668–2677 (Project 3)
Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn KC, Gee SJ, Hammock BD (2014) Determination of the pyrethroid insecticide metabolite 3-PBA in plasma and urine samples from farmer and consumer groups in northern Thailand. J Environ Sci Health B 49(1):15–22 (Project 3)
Trunnelle KJ, Bennett DH, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hennessy-Burt TE, Hammock BD, Schenker MB (2013) Pyrethroids in house dust from the homes of farm worker families in the MICASA study. Environ Int 61:57–63 (Project 3)
Ulu A, Appt S, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD (2012) Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br. J. Pharmacol. 165(5):1401–1412 (Project 5)
Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif A, Liu J, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD (2013) Anti-inflammatory Effects of Omega-3 Polyunsaturated Fatty Acids and Soluble Epoxide Hydrolase Inhibitors in Angiotensin-II Dependent Hypertension. J. Cardiovasc. Pharmacol. (Project 5)
Ulu A, Stephen Lee KS, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD (2014) An Omega-3 Epoxide of Docosahexaenoic Acid Lowers Blood Pressure in Angiotensin-II-Dependent Hypertension. J. Cardiovasc. Pharmacol. 64(1):87–99 (Project 5)
Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD (2013) Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur. J. Pharmacol. 700(1-3):93–101 (Project 5)
Wang Y, Li P, Majkova Z, Bever, Candace R S, Kim HJ, Zhang Q, Dechant JE, Gee SJ, Hammock BD (2013) Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay. Anal. Chem. 85(17):8298–8303 (Project 3)
Wang Y, Wang H, Li P, Zhang Q, Kim HJ, Gee SJ, Hammock BD (2013) Phage-Displayed Peptide That Mimics Aflatoxins and Its Application in Immunoassay. J. Agric. Food Chem. (Core B)
Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433–446 (Project 5)
Yueh M, Li T, Evans RM, Hammock B, Tukey RH (2012) Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS ONE 7(6):e37705 (Project 5)
Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2013) Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530–6535 (Project 5)
Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2014) Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A. (Project 5)
Core A archive from 2005 Apr -2010 Mar Project Period
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